陈文简介
基本情况
陈文(Wen Chen),男,1991年10月出生,助理研究员,博士,主要从事的研究方向:
(1) 生物传感与生物成像:基于化学生物学领域从事有机生物传感的设计合成及生物成像;
(2) 诊疗一体:近红外有机光敏材料的设计合成及荧光引导的肿瘤光动力学治疗研究;
(3) 环境功能材料:多孔材料的合成及改性研究。
E-Mail:wenchen@hnu.edu.cn
教育经历
2017/09—2020/06,湖南大学,化学,博士
2015/09—2017/06,湖南大学,生物医学工程,硕士
2011/09—2015/06,衡阳师范学院,化学,学士
工作经历
2020/07—2022/07 湖南大学,博士后流动站,全职博士后
2022/08—至今 衡阳师范学院 化学与材料科学学院
科研项目
(1) 主持湖南省自然科学基金青年基金项目1项, 2022JJ40034 新型近红外I型光敏剂的设计、合成及肿瘤光动力学治疗研究 在研
(2) 参与国家自然基金面上项目2项, 21974041,活体内遗传编码RNA适体生物传感体系的构建及应用;22174043, 基于细胞内源分子响应的RNA活性调控新策略及其生物成像,2022.01-2025.12, 60万元,在研
(3) 参与国家自然科学基金委员会重大项目1项, 22090053, 纳米孔道单细胞单分子原位测量研究, 2021-01-01 至 2025-12-31, 376万元, 在研
代表论文
[1] Xu, X. B., He, Y. Y., Chen, W.* et al. A near-infrared indicator for sensitive imaging of G-Quadruplexes in live cells. Dyes and Pigments, 2022, 201, 110194.
[2] Chen W., Luo N., Jiang J. H.* et al. An activatable near-infrared fluorescent probe facilitated high-contrast lipophagic imaging in live cells, Chemical Communications, 2021, 57: 8664-8667
[3] Chen W., Han J. Y., Jiang J. H.* et al. Simultaneous Imaging of Lysosomal and Mitochondrial Viscosity During Mitophagy Using Molecular Rotors with Dual-color Emission[J]. Chemical Communication, 2020, 56(56): 7797-7800
[4] Xu, X. B., Chen W., Jiang J. H.* et al. Mitochondrial-targeted near-infrared fluorescence probe for selective detection of fluoride ions in living cells[J]. Talanta, 2019, 204: 655-662.
[5] Chen W., Yang M., Jiang J. H.* et al. An intramolecular charge transfer and excited state intramolecular proton transfer based fluorescent probe for highly selective detection and imaging of formaldehyde in living cells[J]. Analyst, 2019, 144(23): 6922-6927.
[6] Chen W., Gao C., Jiang J. H.* et al. Engineering organelle-specific molecular viscosimeters using aggregation-induced emission luminogens for live cell imaging[J]. Analytical Chemistry, 2018, 90(15): 8736-8741.
[7] Chen W., Han J., Jiang J. H.* et al. Aggregation-Induced Emission-Based Fluorescence Probe for Fast and Sensitive Imaging of Formaldehyde in Living Cells[J]. ACS Omega, 2018, 3(10): 14417-14422.
[8] Chen W., Liu W., Jiang J. H.* et al. A novel fluorescent probe for sensitive detection and imaging of hydrazine in living cells[J]. Talanta, 2017, 162: 225-231.
[9] Liu W., Chen W., Jiang J. H.* et al. An excited-state intramolecular photon transfer fluorescence probe for localizable live cell imaging of cysteine[J]. Methods and Applications in Fluorescence, 2017, 5(1): 014012.
[10] Huang B, Chen W., Jiang J H.* et al. A novel off-on fluorescent probe for sensitive imaging of mitochondria-specific nitroreductase activity in living tumor cells[J]. Organic & Biomolecular Chemistry, 2017.