基本情况：

陈文，男，副教授，湖南省高校青年骨干教师，硕士生导师。主要从事生物传感与光敏材料开发及应用等领域。近 5 年，主持国家自然科学基金青年基金、湖南省自然科学基金青年基金、衡阳市科技创新等项目各 1 项，作为核心骨干参与国家重点研发项目 1 项和国家自然科学基金面上项目 2 项。以通讯作者或第一作者身份发表 SCI 学术论文 20 多篇，包括《Angew. Chem. Int. Ed.》《Chem. Sci.》《Anal. Chem.》《Chem. Commun.》《Sensor Actuat. B-Chem.》《Talanta》《Spectrochim. Acta. A》《Bioorg. Chem.》等。荣获 2023 年度衡阳市“小荷”人才专项资助和衡阳师范学院“英才支持计划”项目等。指导研究生参加湖南省第十七届研究生创新论坛暨“天然产物高值化应用”分论坛荣获一等奖 1 项；中国国际大学生创新大赛荣获二等奖 2 项。

科研项目

(1)主持国家自然科学基金青年项目《双锁型G-四链体RNA激活式成像探针的构建及其光动力学治疗研究》No.22304047，在研。（2024-2026）

(2)主持衡阳市科技创新计划基础项目《RNA靶向激活近红外光敏剂的构建及肿瘤精准光动治疗研究》(202330046097)，在研。（2023-2025）

(3)主持衡阳师范学院“英才支持计划”项目，在研。（2025-2030）

(4)主持衡阳市“小荷”人才专项《双激活精准高效治疗光敏材料的构建及光动治疗研究》HYKY2023048，结题。（2023-2024）

(5)主持生态环境部重金属污染监测重点实验室项目《基于FRET效应构建铀酰离子高灵敏荧光传感器及应用研究》KLMHM202425（主持，在研，2024-2025）

(6)主持湖南省自然科学基金青年基金项目《新型近红外I型光敏剂的设计、合成及肿瘤光动力学治疗研究》2022JJ40034，结题（2022-2024）。

(7)主持衡阳师范学院启动项目《近红外光敏剂的设计、合成及应用研究》2022QD04，结题。

(8)参与国家自然基金面上项目2项， 21974041，活体内遗传编码RNA适体生物传感体系的构建及应用；22174043， 基于细胞内源分子响应的RNA活性调控新策略及其生物成像，2022.01-2025.12，在研

代表论文

[1]Wen Chen,* Xiao-Qiong Mao, Xiao-Zhi Wang, Ya-Cong Liao, Xiao-Yue Yin, Hai-Long Wu, Tai-Yi Chen, Meng-Qing Liu, Tong Wang, Ru-Qin Yu, Data-driven discovery of near-infrared type I photosensitizers for RNA-targeted tumor photodynamic therapy. Chem. Sci., 2025, 16, 14455-14467. (封面文章)

[2]Taiyi Chen, Shufa Long, Junjie Liu, Lu Jiang, Rongying Zeng, Mengqin Liu, Siping Tang, Shuping Zhang, Wen Chen^⁎, Engineering neutral probes for investigating the role of ROS in the formation of G4s by fluorescence imaging in tumor cells. Sensor Actuat. B-Chem., 2025, 444, 138498.

[3]Xuanyuan Wang, Wen Chen*, Shuangling Liu, Yihong Xu, Zhimei Xiong, Yingzi Li, Leyuan Huang, Lu Jiang, Jingting Zhang, Leying Sun, Yuan Zhang*, Mengqin Liu, Detection of mitophagy in live cells with indole derived near-infrared fluorogenic probes, Spectrochim. Acta A, 2025, 340 126368.

[4]Wen Chen, Zhang, Y., Yi, H. B., Wang, F.*., Chu, X., & Jiang, J. H.*. Type I photosensitizer targeting G‐quadruplex RNA elicits augmented immunity for cancer ablation. Angewandte Chemie International Edition, 2023, 62(17), e202300162.

[5]Liao, Y., Lin, X., He, Z., Chen, J., Tang, S., Wang, W.*., Wen Chen^⁎. Construction of nucleus-targeted photosensitizer and highly effective photodynamic immunotherapy for cancer. Bioorganic Chemistry, 2025, 154, 108022.

[6]Liu, J., Sun, L., Hong, Y., Deng, J., Luo, Q., Zeng, R.*, Wen Chen^⁎. Near-infrared fluorescent probe for sensitive detection and imaging of DNA G4s in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 318, 124489.

[7]Lin, X., Chen, T., Hu, J., Mao, X., Liu, M.*,, Zeng, R., Wen Chen^⁎,. Construction of a novel fluorescent probe for sensitive determination of glyphosate in food and imaging living cells. Analytical Methods, 2024, 16(21), 3364-3371.

[8]Long, S., Zhou, J., Zheng, Y., Xiao, Q., Li, Y., Yin, Z.,Wen Chen^⁎, Liu, M.* A NIR fluorescent probe with large stokes shift for sensitive detection and imaging of G4s in live cells. Journal of Photochemistry and Photobiology A: Chemistry, 2024, 455, 115783.

[9] Wen Chen^⁎, Lin, X., Yin, X., Wang, X., Xie, D., Tang, W., Liu, M. An aggregation-induced emission fluorescent probe for highly sensitive and selective detection and imaging of Hg²⁺ in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 303, 123209.

[10] Xu, X. B., He, Y. Y., Wen Chen^⁎ et al. A near-infrared indicator for sensitive imaging of G-Quadruplexes in live cells. Dyes and Pigments, 2022, 201, 110194.

[11] Wen Chen, Luo N., Jiang J. H.* et al. An activatable near-infrared fluorescent probe facilitated high-contrast lipophagic imaging in live cells, Chemical Communications, 2021, 57: 8664-8667

[12] Wen Chen, Han J. Y., Jiang J. H.* et al. Simultaneous Imaging of Lysosomal and Mitochondrial Viscosity During Mitophagy Using Molecular Rotors with Dual-color Emission[J]. Chemical Communication, 2020, 56(56): 7797-7800

[13] Xu, X. B., Wen Chen, Jiang J. H.* et al. Mitochondrial-targeted near-infrared fluorescence probe for selective detection of fluoride ions in living cells[J]. Talanta, 2019, 204: 655-662.

[14] Wen Chen, Yang M., Jiang J. H.* et al. An intramolecular charge transfer and excited state intramolecular proton transfer based fluorescent probe for highly selective detection and imaging of formaldehyde in living cells[J]. Analyst, 2019, 144(23): 6922-6927.

[15] Wen Chen, Han J., Jiang J. H.* et al. Aggregation-Induced Emission-Based Fluorescence Probe for Fast and Sensitive Imaging of Formaldehyde in Living Cells[J]. ACS Omega, 2018, 3(10): 14417-14422.

[16] Wen Chen, Gao C., Jiang J. H.* et al. Engineering organelle-specific molecular viscosimeters using aggregation-induced emission luminogens for live cell imaging[J]. Analytical Chemistry, 2018, 90(15): 8736-8741.

[17] Wen Chen, Liu W., Jiang J. H.* et al. A novel fluorescent probe for sensitive detection and imaging of hydrazine in living cells[J]. Talanta, 2017, 162: 225-231.

[18] Liu W., Wen Chen, Jiang J. H.* et al. An excited-state intramolecular photon transfer fluorescence probe for localizable live cell imaging of cysteine[J]. Methods and Applications in Fluorescence, 2017, 5(1): 014012.

[19] Huang B, Wen Chen, Jiang J H.* et al. A novel off-on fluorescent probe for sensitive imaging of mitochondria-specific nitroreductase activity in living tumor cells[J]. Organic & Biomolecular Chemistry, 2017.

教学方向：

[1] 以第一指导老师身份指导本科生参加第九届湖南省“互联网+”大学生创新创业大赛荣获“二等奖”一项。

[2] 以第一指导老师身份指导本科生参加中国国际大学生创新大赛省赛荣获”三等奖”一项。

[3] 以第一指导老师身份指导本科生参加第二届衡阳师范学院大学生节能减排社会实践与科技竞赛荣获”三等奖”一项。

[4] 以第一指导老师身份指导研究生生参加第二届衡阳师范学院大学生节能减排社会实践与科技竞赛荣获”一等奖”一项。

[5] 以第一指导老师身份指导研究生参加湖南省第十七届研究生创新论坛暨“天然产物高值化应用”分论坛荣获湖南省“一等奖”一项

[6] 以第二指导老师身份指导本科生参加全国大学生节能减排社会实践与科技竞赛荣获一等奖一项。

[7] 以第三指导老师身份指导本科生参加第九届湖南省“互联网+”大学生创新创业大赛荣获二等奖一项。

[8] 以第二指导老师身份指导本科生参加首届湖南省大学生节能减排社会实践与科技竞赛荣获一等奖一项。

[9] 荣获衡阳师范学院2023-2024年度“优秀班主任”称号

[10] 荣获衡阳师范学院2023年度“挑战杯”大学生课外学术科技作品竞赛和大学生创新创业大赛中“优秀指导老师”称号